12/22/2023 0 Comments Brondell balance lock mode![]() Neurons display a striking degree of functional and morphological diversity, and the developmental mechanisms that underlie diversification are of significant interest for understanding neural circuit assembly and function. Our findings are distinctive because, while the classical sd loss of function phenotypes in eye, wing and lymph gland are reported as loss of tissue or reduced organ size, the present study shows that, Sd inactivation in the developing MB, promotes precursor cell proliferation and results in an increase in the organ size. Further Sd in Kenyon cells (KCs) imparts a cell autonomous restriction on their growth. ![]() Sd expressed in the differentiated MB neurons, imposes non-cell autonomous repression on the proliferation of MB precursor cells, and Sd expression in the MB neuroblasts (NB) cell autonomously represses mushroom body neuroblast (MBNB) proliferation. We demonstrate that, sd regulation on MB size operates through multiple routes. We show that, sd non-function results in an increase in the size of MBs. Here we have studied the hypomorphic effect of sd on the development of Mushroom Bodies (MBs) in Drosophila brain. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evolutionarily conserved regulator of organ size. This work provides the necessary foundation for functional studies regarding the roles of sd during Drosophila development.Ĭell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. We describe the full breadth of SD expression during Drosophila embryogenesis, and identify a requirement for sd function in a subset of motor neurons. We also show that SD and vg protein (VG) are co-expressed in overlapping and distinctive subsets of cells in embryonic and larval tissues. ![]() While sd function is not required to specify these neurons, it is necessary for the correct innervation of somatic muscles by the mVUMs. SD is also expressed in subsets of ventral nerve cord cells, including neuroblast 1-2 descendants and ventral unpaired median motor neurons (mVUMs). Despite SD expression herein, the peripheral nervous system, musculature, and dorsal limb primordia appeared generally normal in the absence of sd function. SD is also expressed in developing flight appendages. To begin to address these questions, we generated an anti-SD antibody.ĭuring embryogenesis, SD is expressed in both central and peripheral nervous systems, and the musculature. Little is known about sd protein (SD) expression during development, or whether sd and vg interact in other developing tissues. The scalloped (sd) and vestigial (vg) genes function together in Drosophila wing development.
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